Its first founders were the Hittites. Later, Phrygians and Lydians dominated the region. BC 6. century, the region came under the domination of Persians. As a result of the earthquake disaster that occurred in 264-238 BC, the people left Nysa and migrated to present-day Sultanhisar. After the rule of Macedonia, Selevkkos and Bergama respectively, these lands came under the sovereignty of the Roman Empire in 64 BC. After the Byzantine period, Menteşeoğulları dominated the environment. The city, which was captured by the Aydınoğulları Principality in 1308 at the beginning of the 14th century, became the Ottomans in 1390. Although it came under the sovereignty of Aydınoğulları for a while after the Ankara War, it joined the Ottoman lands again in 1425.
Aydın Bey’s daughter named “Nilüfer Sultan” refers to the district; It is said that the name “Sultanhisar” comes from here because it accepts it as “Hisar”. The south of the district is on the fertile lands of Büyük Menderes. For this reason, the livelihood of the people is generally based on agriculture. Greenhouse cultivation is highly developed. It is the most orange and peach growing district of Aydın. Major industrial establishments are olive oil and cotton factories. The passage of the Izmir-Afyon railway and the Izmir-Denizli Highway through the city positively affects transportation and trade.